Variants - Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation

Variant data
Allele	Unknown
Reported pathogenicity	Unknown
Concluded pathogenicity	Unknown
Exon	11
DNA change	c.1258G>T
BIC DNA change	1377G>T
Protein change	p.D420Y
Posterior P	0.01418
IARC Class	2 - Likely not pathogenic or of little clinical significance
Key Observational Reference	Easton et al. 2007
Prior P reference	Vallee et al. 2016
Missense analysis Prior P	0.02
Splicing prior P	0.64
Other Prior P	0.00
Combined prior P	0.64
Segregation LR	1
Pathology LR	-
Sum Family LR	6.92E-03
Co-occurrence LR	1.17
case-control LR	-
Product of LRs	8.09E-03
Comments	-
DB-ID	BRCA1_00152

1 entry in BRCA1

Path.

Allele

Exon

DNA change

BIC DNA change

Protein change

Posterior P

IARC Class

Key Observational Reference

Prior P reference

Missense analysis Prior P

Splicing prior P

Other Prior P

Combined prior P

Segregation LR

Pathology LR

Sum Family LR

Co-occurrence LR

case-control LR

Product of LRs

Comments

DB-ID

?/?

Unknown

1377G>T

p.D420Y

0.01418

2 - Likely not pathogenic or of little clinical significance

0.02

0.64

0.00

0.64

6.92E-03

1.17

8.09E-03

BRCA1_00152

Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation