Variants - Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation

Variant data
Allele	Unknown
Reported pathogenicity	-
Concluded pathogenicity	No known pathogenicity
Exon	11
DNA change	c.1106_1108del
BIC DNA change	1225del3
Protein change	p.D369del
Posterior P	3.97862E-07
IARC Class	1 - Not pathogenic or of no clinical significance
Key Observational Reference	Parsons et al 2019
Prior P reference	-
Missense analysis Prior P	-
Splicing prior P	-
Other Prior P	0.02
Combined prior P	0.02
Segregation LR	0.0116
Pathology LR	0.57
Sum Family LR	0.049112297
Co-occurrence LR	0.060035116
case-control LR	-
Product of LRs	0.0000194952
Comments	-
DB-ID	BRCA1_00205

1 entry in BRCA1

Path.

Allele

Exon

DNA change

BIC DNA change

Protein change

Posterior P

IARC Class

Key Observational Reference

Prior P reference

Missense analysis Prior P

Splicing prior P

Other Prior P

Combined prior P

Segregation LR

Pathology LR

Sum Family LR

Co-occurrence LR

case-control LR

Product of LRs

Comments

DB-ID

Unknown

1225del3

p.D369del

3.97862E-07

1 - Not pathogenic or of no clinical significance

Parsons et al 2019

0.02

0.0116

0.57

0.049112297

0.060035116

0.0000194952

BRCA1_00205

Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation