Variants - Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation

Variant data
Allele	Unknown
Reported pathogenicity	-
Concluded pathogenicity	No known pathogenicity
Exon	11
DNA change	c.1703C>T
BIC DNA change	1822C>T
Protein change	p.P568L
Posterior P	8.19421E-06
IARC Class	1 - Not pathogenic or of no clinical significance
Key Observational Reference	Parsons et al 2019
Prior P reference	-
Missense analysis Prior P	0.02
Splicing prior P	-
Other Prior P	0.02
Combined prior P	0.02
Segregation LR	0.0395
Pathology LR	0.01539
Sum Family LR	0.418721101
Co-occurrence LR	1.577415842
case-control LR	-
Product of LRs	0.00040152
Comments	-
DB-ID	BRCA1_00251

1 entry in BRCA1

Path.

Allele

Exon

DNA change

BIC DNA change

Protein change

Posterior P

IARC Class

Key Observational Reference

Prior P reference

Missense analysis Prior P

Splicing prior P

Other Prior P

Combined prior P

Segregation LR

Pathology LR

Sum Family LR

Co-occurrence LR

case-control LR

Product of LRs

Comments

DB-ID

Unknown

1822C>T

p.P568L

8.19421E-06

1 - Not pathogenic or of no clinical significance

Parsons et al 2019

0.02

0.0395

0.01539

0.418721101

1.577415842

0.00040152

BRCA1_00251

Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation