Variants - Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation

Variant data
Allele	Unknown
Reported pathogenicity	-
Concluded pathogenicity	No known pathogenicity
Exon	11
DNA change	c.1846_1848del
BIC DNA change	1965del3
Protein change	p.S616del
Posterior P	5.40107E-06
IARC Class	1 - Not pathogenic or of no clinical significance
Key Observational Reference	Parsons et al 2019
Prior P reference	-
Missense analysis Prior P	-
Splicing prior P	-
Other Prior P	0.02
Combined prior P	0.02
Segregation LR	-
Pathology LR	0.00112896
Sum Family LR	1.730290135
Co-occurrence LR	0.135481723
case-control LR	-
Product of LRs	0.000264654
Comments	-
DB-ID	BRCA1_00264

1 entry in BRCA1

Path.

Allele

Exon

DNA change

BIC DNA change

Protein change

Posterior P

IARC Class

Key Observational Reference

Prior P reference

Missense analysis Prior P

Splicing prior P

Other Prior P

Combined prior P

Segregation LR

Pathology LR

Sum Family LR

Co-occurrence LR

case-control LR

Product of LRs

Comments

DB-ID

Unknown

1965del3

p.S616del

5.40107E-06

1 - Not pathogenic or of no clinical significance

Parsons et al 2019

0.02

0.00112896

1.730290135

0.135481723

0.000264654

BRCA1_00264

Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation