Variants - Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation

Variant data
Allele	Unknown
Reported pathogenicity	-
Concluded pathogenicity	No known pathogenicity
Exon	12
DNA change	c.4185+10G>C
BIC DNA change	IVS12+10G>C
Protein change	-
Posterior P	0.000128868
IARC Class	1 - Not pathogenic or of no clinical significance
Key Observational Reference	Parsons et al 2019
Prior P reference	-
Missense analysis Prior P	-
Splicing prior P	-
Other Prior P	0.02
Combined prior P	0.02
Segregation LR	-
Pathology LR	0.51
Sum Family LR	0.336129918
Co-occurrence LR	0.036840044
case-control LR	-
Product of LRs	0.006315351
Comments	-
DB-ID	BRCA1_00450

1 entry in BRCA1

Path.

Allele

Exon

DNA change

BIC DNA change

Protein change

Posterior P

IARC Class

Key Observational Reference

Prior P reference

Missense analysis Prior P

Splicing prior P

Other Prior P

Combined prior P

Segregation LR

Pathology LR

Sum Family LR

Co-occurrence LR

case-control LR

Product of LRs

Comments

DB-ID

Unknown

IVS12+10G>C

0.000128868

1 - Not pathogenic or of no clinical significance

Parsons et al 2019

0.02

0.51

0.336129918

0.036840044

0.006315351

BRCA1_00450

Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation