Variants - Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation

Variant data
Allele	Unknown
Reported pathogenicity	-
Concluded pathogenicity	Probably no pathogenicity
Exon	13
DNA change	c.4213A>G
BIC DNA change	4332A>G
Protein change	p.I1405V
Posterior P	0.001564304
IARC Class	2 - Likely not pathogenic or of little clinical significance
Key Observational Reference	Parsons et al 2019
Prior P reference	-
Missense analysis Prior P	0.02
Splicing prior P	-
Other Prior P	0.02
Combined prior P	0.3
Segregation LR	-
Pathology LR	0.148
Sum Family LR	0.383841549
Co-occurrence LR	0.034517721
case-control LR	1.864327003
Product of LRs	0.003655762
Comments	-
DB-ID	BRCA1_00464

1 entry in BRCA1

Path.

Allele

Exon

DNA change

BIC DNA change

Protein change

Posterior P

IARC Class

Key Observational Reference

Prior P reference

Missense analysis Prior P

Splicing prior P

Other Prior P

Combined prior P

Segregation LR

Pathology LR

Sum Family LR

Co-occurrence LR

case-control LR

Product of LRs

Comments

DB-ID

Unknown

4332A>G

p.I1405V

0.001564304

2 - Likely not pathogenic or of little clinical significance

Parsons et al 2019

0.02

0.3

0.148

0.383841549

0.034517721

1.864327003

0.003655762

BRCA1_00464

Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation