Variants - Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation

Variant data
Allele	Unknown
Reported pathogenicity	-
Concluded pathogenicity	No known pathogenicity
Exon	16
DNA change	c.4816A>G
BIC DNA change	4935A>G
Protein change	p.K1606E
Posterior P	0.000265668
IARC Class	1 - Not pathogenic or of no clinical significance
Key Observational Reference	Parsons et al 2019
Prior P reference	-
Missense analysis Prior P	0.02
Splicing prior P	-
Other Prior P	0.02
Combined prior P	0.02
Segregation LR	0.081900008
Pathology LR	-
Sum Family LR	0.114809233
Co-occurrence LR	1.384809842
case-control LR	-
Product of LRs	0.013021197
Comments	-
DB-ID	BRCA1_00519

1 entry in BRCA1

Path.

Allele

Exon

DNA change

BIC DNA change

Protein change

Posterior P

IARC Class

Key Observational Reference

Prior P reference

Missense analysis Prior P

Splicing prior P

Other Prior P

Combined prior P

Segregation LR

Pathology LR

Sum Family LR

Co-occurrence LR

case-control LR

Product of LRs

Comments

DB-ID

Unknown

4935A>G

p.K1606E

0.000265668

1 - Not pathogenic or of no clinical significance

Parsons et al 2019

0.02

0.081900008

0.114809233

1.384809842

0.013021197

BRCA1_00519

Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation