Variants - Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation

Variant data
Allele	Unknown
Reported pathogenicity	-
Concluded pathogenicity	Probably no pathogenicity
Exon	1
DNA change	c.-19-10T>C
BIC DNA change	IVS1-10T>C
Protein change	-
Posterior P	0.01599425
IARC Class	2 - Likely not pathogenic or of little clinical significance
Key Observational Reference	Parsons et al 2019
Prior P reference	-
Missense analysis Prior P	-
Splicing prior P	0.34
Other Prior P	0.02
Combined prior P	0.34
Segregation LR	0.0626
Pathology LR	-
Sum Family LR	0.2383744
Co-occurrence LR	2.114449539
case-control LR	-
Product of LRs	0.031552318
Comments	-
DB-ID	BRCA1_00626

1 entry in BRCA1

Path.

Allele

Exon

DNA change

BIC DNA change

Protein change

Posterior P

IARC Class

Key Observational Reference

Prior P reference

Missense analysis Prior P

Splicing prior P

Other Prior P

Combined prior P

Segregation LR

Pathology LR

Sum Family LR

Co-occurrence LR

case-control LR

Product of LRs

Comments

DB-ID

Unknown

IVS1-10T>C

0.01599425

2 - Likely not pathogenic or of little clinical significance

Parsons et al 2019

0.34

0.02

0.34

0.0626

0.2383744

2.114449539

0.031552318

BRCA1_00626

Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation