Variants - Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation

Variant data
Allele	Unknown
Reported pathogenicity	-
Concluded pathogenicity	No known pathogenicity
Exon	11
DNA change	c.716A>G
BIC DNA change	835A>G
Protein change	p.H239R
Posterior P	0.000925328
IARC Class	1 - Not pathogenic or of no clinical significance
Key Observational Reference	Parsons et al 2019
Prior P reference	-
Missense analysis Prior P	0.02
Splicing prior P	-
Other Prior P	0.02
Combined prior P	0.02
Segregation LR	0.9986
Pathology LR	-
Sum Family LR	0.041217819
Co-occurrence LR	1.102597599
case-control LR	-
Product of LRs	0.045383043
Comments	-
DB-ID	BRCA1_00639

1 entry in BRCA1

Path.

Allele

Exon

DNA change

BIC DNA change

Protein change

Posterior P

IARC Class

Key Observational Reference

Prior P reference

Missense analysis Prior P

Splicing prior P

Other Prior P

Combined prior P

Segregation LR

Pathology LR

Sum Family LR

Co-occurrence LR

case-control LR

Product of LRs

Comments

DB-ID

Unknown

835A>G

p.H239R

0.000925328

1 - Not pathogenic or of no clinical significance

Parsons et al 2019

0.02

0.9986

0.041217819

1.102597599

0.045383043

BRCA1_00639

Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation