Variants - Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation

Variant data
Allele	Unknown
Reported pathogenicity	-
Concluded pathogenicity	No known pathogenicity
Exon	6
DNA change	c.301+7G>A
BIC DNA change	IVS6+7G>A
Protein change	-
Posterior P	9.89343E-13
IARC Class	1 - Not pathogenic or of no clinical significance
Key Observational Reference	Parsons et al 2019
Prior P reference	-
Missense analysis Prior P	-
Splicing prior P	-
Other Prior P	0.02
Combined prior P	0.02
Segregation LR	1.363440054
Pathology LR	0.001087452
Sum Family LR	0.037415892
Co-occurrence LR	0.068385089
case-control LR	1.27785E-05
Product of LRs	4.84778e-11
Comments	-
DB-ID	BRCA1_00653

1 entry in BRCA1

Path.

Allele

Exon

DNA change

BIC DNA change

Protein change

Posterior P

IARC Class

Key Observational Reference

Prior P reference

Missense analysis Prior P

Splicing prior P

Other Prior P

Combined prior P

Segregation LR

Pathology LR

Sum Family LR

Co-occurrence LR

case-control LR

Product of LRs

Comments

DB-ID

Unknown

IVS6+7G>A

9.89343E-13

1 - Not pathogenic or of no clinical significance

Parsons et al 2019

0.02

1.363440054

0.001087452

0.037415892

0.068385089

1.27785E-05

4.84778e-11

BRCA1_00653

Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation