Variants - Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation

Variant data
Allele	Unknown
Reported pathogenicity	-
Concluded pathogenicity	No known pathogenicity
Exon	11
DNA change	c.827C>G
BIC DNA change	946C>G
Protein change	p.T276R
Posterior P	4.5123E-05
IARC Class	1 - Not pathogenic or of no clinical significance
Key Observational Reference	Parsons et al 2019
Prior P reference	-
Missense analysis Prior P	0.02
Splicing prior P	-
Other Prior P	0.02
Combined prior P	0.02
Segregation LR	0.3303
Pathology LR	0.196
Sum Family LR	0.029984209
Co-occurrence LR	1.1390848
case-control LR	-
Product of LRs	0.002211125
Comments	-
DB-ID	BRCA1_00663

1 entry in BRCA1

Path.

Allele

Exon

DNA change

BIC DNA change

Protein change

Posterior P

IARC Class

Key Observational Reference

Prior P reference

Missense analysis Prior P

Splicing prior P

Other Prior P

Combined prior P

Segregation LR

Pathology LR

Sum Family LR

Co-occurrence LR

case-control LR

Product of LRs

Comments

DB-ID

Unknown

946C>G

p.T276R

4.5123E-05

1 - Not pathogenic or of no clinical significance

Parsons et al 2019

0.02

0.3303

0.196

0.029984209

1.1390848

0.002211125

BRCA1_00663

Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation