Variants - Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation

Variant data
Allele	Unknown
Reported pathogenicity	-
Concluded pathogenicity	No known pathogenicity
Exon	1
DNA change	c.-19-3A>G
BIC DNA change	IVS1-3A>G
Protein change	-
Posterior P	0.000863879
IARC Class	1 - Not pathogenic or of no clinical significance
Key Observational Reference	Parsons et al 2019
Prior P reference	-
Missense analysis Prior P	-
Splicing prior P	0.97
Other Prior P	0.02
Combined prior P	0.97
Segregation LR	-
Pathology LR	1
Sum Family LR	-
Co-occurrence LR	-
case-control LR	2.6741E-05
Product of LRs	0.000026741
Comments	-
DB-ID	BRCA1_00272

1 entry in BRCA1

Path.

Allele

Exon

DNA change

BIC DNA change

Protein change

Posterior P

IARC Class

Key Observational Reference

Prior P reference

Missense analysis Prior P

Splicing prior P

Other Prior P

Combined prior P

Segregation LR

Pathology LR

Sum Family LR

Co-occurrence LR

case-control LR

Product of LRs

Comments

DB-ID

Unknown

IVS1-3A>G

0.000863879

1 - Not pathogenic or of no clinical significance

Parsons et al 2019

0.97

0.02

0.97

2.6741E-05

0.000026741

BRCA1_00272

Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation