Variants - Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation

Variant data
Allele	Unknown
Reported pathogenicity	Unknown
Concluded pathogenicity	Unknown
Exon	15
DNA change	c.7436-14T>G
BIC DNA change	IVS14-14T>G
Protein change	-
Posterior P	0.001
IARC Class	1 - Not pathogenic or of no clinical significance
Key Observational Reference	Whiley et al., Human Mutation 32: 678-687, 2011
Prior P reference	Vallee MP et al., Human Mutation 37: 627-639, 2016
Missense analysis Prior P	-
Splicing prior P	0.04
Other Prior P	0.00
Combined prior P	0.04
Segregation LR	0.37
Pathology LR	-
Sum Family LR	1.05
Co-occurrence LR	0.05
case-control LR	-
Product of LRs	0.02
Comments	-

1 entry in BRCA2

Path.

Allele

Exon

DNA change

BIC DNA change

Protein change

Posterior P

IARC Class

Key Observational Reference

Prior P reference

Missense analysis Prior P

Splicing prior P

Other Prior P

Combined prior P

Segregation LR

Pathology LR

Sum Family LR

Co-occurrence LR

case-control LR

Product of LRs

Comments

?/?

Unknown

IVS14-14T>G

0.001

1 - Not pathogenic or of no clinical significance

Whiley et al., Human Mutation 32: 678-687, 2011

Vallee MP et al., Human Mutation 37: 627-639, 2016

0.04

0.00

0.04

0.37

1.05

0.05

0.02

Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation