Variants - Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation

Variant data
Allele	Unknown
Reported pathogenicity	Unknown
Concluded pathogenicity	Unknown
Exon	25
DNA change	c.9501+3A>T
BIC DNA change	IVS25+3A>T
Protein change	-
Posterior P	0.724
IARC Class	3 - Uncertain
Key Observational Reference	Whiley et al., Human Mutation 32: 678-687, 2011
Prior P reference	Vallee MP et al., Human Mutation 37: 627-639, 2016
Missense analysis Prior P	-
Splicing prior P	0.34
Other Prior P	0.00
Combined prior P	0.34
Segregation LR	0.74
Pathology LR	1.19
Sum Family LR	2.29
Co-occurrence LR	2.52
case-control LR	-
Product of LRs	5.08
Comments	-

1 entry in BRCA2

Path.

Allele

Exon

DNA change

BIC DNA change

Protein change

Posterior P

IARC Class

Key Observational Reference

Prior P reference

Missense analysis Prior P

Splicing prior P

Other Prior P

Combined prior P

Segregation LR

Pathology LR

Sum Family LR

Co-occurrence LR

case-control LR

Product of LRs

Comments

?/?

Unknown

IVS25+3A>T

0.724

3 - Uncertain

Whiley et al., Human Mutation 32: 678-687, 2011

Vallee MP et al., Human Mutation 37: 627-639, 2016

0.34

0.00

0.34

0.74

1.19

2.29

2.52

5.08

Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation