Variants - Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation

Variant data
Allele	Unknown
Reported pathogenicity	-
Concluded pathogenicity	No known pathogenicity
Exon	25
DNA change	c.9502-12T>G
BIC DNA change	IVS25-12T>G
Protein change	-
Posterior P	3.99929E-07
IARC Class	1 - Not pathogenic or of no clinical significance
Key Observational Reference	Parsons et al 2019
Prior P reference	-
Missense analysis Prior P	-
Splicing prior P	0.34
Other Prior P	0.02
Combined prior P	0.34
Segregation LR	0.76769076
Pathology LR	0.014379899
Sum Family LR	-
Co-occurrence LR	-
case-control LR	7.03243E-05
Product of LRs	0.000000776332
Comments	-

1 entry in BRCA2

Path.

Allele

Exon

DNA change

BIC DNA change

Protein change

Posterior P

IARC Class

Key Observational Reference

Prior P reference

Missense analysis Prior P

Splicing prior P

Other Prior P

Combined prior P

Segregation LR

Pathology LR

Sum Family LR

Co-occurrence LR

case-control LR

Product of LRs

Comments

Unknown

IVS25-12T>G

3.99929E-07

1 - Not pathogenic or of no clinical significance

Parsons et al 2019

0.34

0.02

0.34

0.76769076

0.014379899

7.03243E-05

0.000000776332

Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation