Variants - Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation

Variant data
Allele	Unknown
Reported pathogenicity	-
Concluded pathogenicity	Probably pathogenic
Exon	24
DNA change	c.9257-1G>C
BIC DNA change	IVS24-1G>C
Protein change	-
Posterior P	0.965446935
IARC Class	4 - Likely Pathogenic
Key Observational Reference	Parsons et al 2019
Prior P reference	-
Missense analysis Prior P	-
Splicing prior P	0.34
Other Prior P	0.02
Combined prior P	0.34
Segregation LR	1.292905831
Pathology LR	0.7632
Sum Family LR	47.50467539
Co-occurrence LR	1.157084926
case-control LR	-
Product of LRs	54.23839711
Comments	-

1 entry in BRCA2

Path.

Allele

Exon

DNA change

BIC DNA change

Protein change

Posterior P

IARC Class

Key Observational Reference

Prior P reference

Missense analysis Prior P

Splicing prior P

Other Prior P

Combined prior P

Segregation LR

Pathology LR

Sum Family LR

Co-occurrence LR

case-control LR

Product of LRs

Comments

Unknown

IVS24-1G>C

0.965446935

4 - Likely Pathogenic

Parsons et al 2019

0.34

0.02

0.34

1.292905831

0.7632

47.50467539

1.157084926

54.23839711

Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation