Variants - Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation

Variant data
Allele	Unknown
Reported pathogenicity	-
Concluded pathogenicity	No known pathogenicity
Exon	10
DNA change	c.1796C>T
BIC DNA change	2024C>T
Protein change	p.S599F
Posterior P	0.000315326
IARC Class	1 - Not pathogenic or of no clinical significance
Key Observational Reference	Parsons et al 2019
Prior P reference	-
Missense analysis Prior P	0.02
Splicing prior P	-
Other Prior P	0.02
Combined prior P	0.02
Segregation LR	3.2721192
Pathology LR	0.004723496
Sum Family LR	-
Co-occurrence LR	-
case-control LR	-
Product of LRs	0.015455841
Comments	-

1 entry in BRCA2

Path.

Allele

Exon

DNA change

BIC DNA change

Protein change

Posterior P

IARC Class

Key Observational Reference

Prior P reference

Missense analysis Prior P

Splicing prior P

Other Prior P

Combined prior P

Segregation LR

Pathology LR

Sum Family LR

Co-occurrence LR

case-control LR

Product of LRs

Comments

Unknown

2024C>T

p.S599F

0.000315326

1 - Not pathogenic or of no clinical significance

Parsons et al 2019

0.02

3.2721192

0.004723496

0.015455841

Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation