Variants - Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation

Variant data
Allele	Unknown
Reported pathogenicity	-
Concluded pathogenicity	No known pathogenicity
Exon	10
DNA change	c.1810A>G
BIC DNA change	2038A>G
Protein change	p.K604E
Posterior P	0.000415402
IARC Class	1 - Not pathogenic or of no clinical significance
Key Observational Reference	Parsons et al 2019
Prior P reference	-
Missense analysis Prior P	0.02
Splicing prior P	-
Other Prior P	0.02
Combined prior P	0.02
Segregation LR	0.40400002
Pathology LR	-
Sum Family LR	0.028119201
Co-occurrence LR	1.792507344
case-control LR	-
Product of LRs	0.020363166
Comments	-

1 entry in BRCA2

Path.

Allele

Exon

DNA change

BIC DNA change

Protein change

Posterior P

IARC Class

Key Observational Reference

Prior P reference

Missense analysis Prior P

Splicing prior P

Other Prior P

Combined prior P

Segregation LR

Pathology LR

Sum Family LR

Co-occurrence LR

case-control LR

Product of LRs

Comments

Unknown

2038A>G

p.K604E

0.000415402

1 - Not pathogenic or of no clinical significance

Parsons et al 2019

0.02

0.40400002

0.028119201

1.792507344

0.020363166

Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation