Variants - Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation

Variant data
Allele	Unknown
Reported pathogenicity	-
Concluded pathogenicity	No known pathogenicity
Exon	11
DNA change	c.4146_4148del
BIC DNA change	4374del3
Protein change	-
Posterior P	1.46195E-06
IARC Class	1 - Not pathogenic or of no clinical significance
Key Observational Reference	Parsons et al 2019
Prior P reference	-
Missense analysis Prior P	-
Splicing prior P	-
Other Prior P	0.02
Combined prior P	0.02
Segregation LR	0.00045009
Pathology LR	0.81
Sum Family LR	0.115081821
Co-occurrence LR	1.707415377
case-control LR	-
Product of LRs	0.0000716358
Comments	-

1 entry in BRCA2

Path.

Allele

Exon

DNA change

BIC DNA change

Protein change

Posterior P

IARC Class

Key Observational Reference

Prior P reference

Missense analysis Prior P

Splicing prior P

Other Prior P

Combined prior P

Segregation LR

Pathology LR

Sum Family LR

Co-occurrence LR

case-control LR

Product of LRs

Comments

Unknown

4374del3

1.46195E-06

1 - Not pathogenic or of no clinical significance

Parsons et al 2019

0.02

0.00045009

0.81

0.115081821

1.707415377

0.0000716358

Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation