Variants - Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation

Variant data
Allele	Unknown
Reported pathogenicity	-
Concluded pathogenicity	No known pathogenicity
Exon	11
DNA change	c.6290C>T
BIC DNA change	6518C>T
Protein change	p.T2097M
Posterior P	0.000217082
IARC Class	1 - Not pathogenic or of no clinical significance
Key Observational Reference	Parsons et al 2019
Prior P reference	-
Missense analysis Prior P	0.02
Splicing prior P	-
Other Prior P	0.02
Combined prior P	0.02
Segregation LR	0.00976605
Pathology LR	1.904367168
Sum Family LR	0.459617494
Co-occurrence LR	1.244651749
case-control LR	-
Product of LRs	0.010639324
Comments	-

1 entry in BRCA2

Path.

Allele

Exon

DNA change

BIC DNA change

Protein change

Posterior P

IARC Class

Key Observational Reference

Prior P reference

Missense analysis Prior P

Splicing prior P

Other Prior P

Combined prior P

Segregation LR

Pathology LR

Sum Family LR

Co-occurrence LR

case-control LR

Product of LRs

Comments

Unknown

6518C>T

p.T2097M

0.000217082

1 - Not pathogenic or of no clinical significance

Parsons et al 2019

0.02

0.00976605

1.904367168

0.459617494

1.244651749

0.010639324

Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation