Variants - Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation

Variant data
Allele	Unknown
Reported pathogenicity	-
Concluded pathogenicity	No known pathogenicity
Exon	2
DNA change	c.67+82C>G
BIC DNA change	IVS2+82C>G
Protein change	-
Posterior P	7.8219E-136
IARC Class	1 - Not pathogenic or of no clinical significance
Key Observational Reference	Parsons et al 2019
Prior P reference	-
Missense analysis Prior P	-
Splicing prior P	-
Other Prior P	0.02
Combined prior P	0.02
Segregation LR	-
Pathology LR	1.46786E-18
Sum Family LR	-
Co-occurrence LR	-
case-control LR	2.6111E-116
Product of LRs	3.8327e-134
Comments	-

1 entry in BRCA2

Path.

Allele

Exon

DNA change

BIC DNA change

Protein change

Posterior P

IARC Class

Key Observational Reference

Prior P reference

Missense analysis Prior P

Splicing prior P

Other Prior P

Combined prior P

Segregation LR

Pathology LR

Sum Family LR

Co-occurrence LR

case-control LR

Product of LRs

Comments

Unknown

IVS2+82C>G

7.8219E-136

1 - Not pathogenic or of no clinical significance

Parsons et al 2019

0.02

1.46786E-18

2.6111E-116

3.8327e-134

Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation