Variants - Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation

Variant data
Allele	Unknown
Reported pathogenicity	-
Concluded pathogenicity	No known pathogenicity
Exon	14
DNA change	c.7057G>C
BIC DNA change	7285G>C
Protein change	p.G2353R
Posterior P	0.000781968
IARC Class	1 - Not pathogenic or of no clinical significance
Key Observational Reference	Parsons et al 2019
Prior P reference	-
Missense analysis Prior P	0.02
Splicing prior P	-
Other Prior P	0.02
Combined prior P	0.02
Segregation LR	0.344999994
Pathology LR	0.795857046
Sum Family LR	0.937791035
Co-occurrence LR	0.079024989
case-control LR	1.884516129
Product of LRs	0.038346394
Comments	-

1 entry in BRCA2

Path.

Allele

Exon

DNA change

BIC DNA change

Protein change

Posterior P

IARC Class

Key Observational Reference

Prior P reference

Missense analysis Prior P

Splicing prior P

Other Prior P

Combined prior P

Segregation LR

Pathology LR

Sum Family LR

Co-occurrence LR

case-control LR

Product of LRs

Comments

Unknown

7285G>C

p.G2353R

0.000781968

1 - Not pathogenic or of no clinical significance

Parsons et al 2019

0.02

0.344999994

0.795857046

0.937791035

0.079024989

1.884516129

0.038346394

Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation