Variants - Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation

Variant data
Allele	Unknown
Reported pathogenicity	-
Concluded pathogenicity	-
Exon	17
DNA change	c.7806-2_7806-1dup
BIC DNA change	IVS16-2insAG
Protein change	-
Posterior P	0.999736734
IARC Class	5 - Pathogenic
Key Observational Reference	Parsons et al 2019
Prior P reference	-
Missense analysis Prior P	-
Splicing prior P	-
Other Prior P	0.02
Combined prior P	0.99
Segregation LR	8.7662
Pathology LR	4.37566656
Sum Family LR	-
Co-occurrence LR	-
case-control LR	-
Product of LRs	38.3579682
Comments	-

1 entry in BRCA2

Path.

Allele

Exon

DNA change

BIC DNA change

Protein change

Posterior P

IARC Class

Key Observational Reference

Prior P reference

Missense analysis Prior P

Splicing prior P

Other Prior P

Combined prior P

Segregation LR

Pathology LR

Sum Family LR

Co-occurrence LR

case-control LR

Product of LRs

Comments

Unknown

IVS16-2insAG

0.999736734

5 - Pathogenic

Parsons et al 2019

0.02

0.99

8.7662

4.37566656

38.3579682

Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation