Variants - Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation

Variant data
Allele	Unknown
Reported pathogenicity	-
Concluded pathogenicity	No known pathogenicity
Exon	13
DNA change	c.7008-62A>G
BIC DNA change	IVS13-62A>G
Protein change	-
Posterior P	8.8256E-264
IARC Class	1 - Not pathogenic or of no clinical significance
Key Observational Reference	Parsons et al 2019
Prior P reference	-
Missense analysis Prior P	-
Splicing prior P	-
Other Prior P	0.02
Combined prior P	0.02
Segregation LR	1.832064862
Pathology LR	1.43283E-28
Sum Family LR	-
Co-occurrence LR	-
case-control LR	1.6474E-234
Product of LRs	4.3245e-262
Comments	-

1 entry in BRCA2

Path.

Allele

Exon

DNA change

BIC DNA change

Protein change

Posterior P

IARC Class

Key Observational Reference

Prior P reference

Missense analysis Prior P

Splicing prior P

Other Prior P

Combined prior P

Segregation LR

Pathology LR

Sum Family LR

Co-occurrence LR

case-control LR

Product of LRs

Comments

Unknown

IVS13-62A>G

8.8256E-264

1 - Not pathogenic or of no clinical significance

Parsons et al 2019

0.02

1.832064862

1.43283E-28

1.6474E-234

4.3245e-262

Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation