Variants - Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation

Variant data
Allele	Unknown
Reported pathogenicity	-
Concluded pathogenicity	No known pathogenicity
Exon	18
DNA change	c.8182G>A
BIC DNA change	8410G>A
Protein change	p.V2728I
Posterior P	0.000345012
IARC Class	1 - Not pathogenic or of no clinical significance
Key Observational Reference	Parsons et al 2019
Prior P reference	-
Missense analysis Prior P	0.03
Splicing prior P	-
Other Prior P	0.02
Combined prior P	0.03
Segregation LR	7.607259039
Pathology LR	0.001466919
Sum Family LR	-
Co-occurrence LR	-
case-control LR	-
Product of LRs	0.011159236
Comments	-

1 entry in BRCA2

Path.

Allele

Exon

DNA change

BIC DNA change

Protein change

Posterior P

IARC Class

Key Observational Reference

Prior P reference

Missense analysis Prior P

Splicing prior P

Other Prior P

Combined prior P

Segregation LR

Pathology LR

Sum Family LR

Co-occurrence LR

case-control LR

Product of LRs

Comments

Unknown

8410G>A

p.V2728I

0.000345012

1 - Not pathogenic or of no clinical significance

Parsons et al 2019

0.03

0.02

0.03

7.607259039

0.001466919

0.011159236

Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation