Variants - Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation

Variant data
Allele	Unknown
Reported pathogenicity	-
Concluded pathogenicity	Probably no pathogenicity
Exon	25
DNA change	c.9275A>G
BIC DNA change	9503A>G
Protein change	p.Y3092C
Posterior P	0.031992835
IARC Class	2 - Likely not pathogenic or of little clinical significance
Key Observational Reference	Parsons et al 2019
Prior P reference	-
Missense analysis Prior P	0.81
Splicing prior P	-
Other Prior P	0.02
Combined prior P	0.81
Segregation LR	1.160082
Pathology LR	1.1342
Sum Family LR	0.004620146
Co-occurrence LR	1.275289324
case-control LR	-
Product of LRs	0.007752517
Comments	-

1 entry in BRCA2

Path.

Allele

Exon

DNA change

BIC DNA change

Protein change

Posterior P

IARC Class

Key Observational Reference

Prior P reference

Missense analysis Prior P

Splicing prior P

Other Prior P

Combined prior P

Segregation LR

Pathology LR

Sum Family LR

Co-occurrence LR

case-control LR

Product of LRs

Comments

Unknown

9503A>G

p.Y3092C

0.031992835

2 - Likely not pathogenic or of little clinical significance

Parsons et al 2019

0.81

0.02

0.81

1.160082

1.1342

0.004620146

1.275289324

0.007752517

Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation