Variants - Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation

Variant data
Allele	Unknown
Reported pathogenicity	-
Concluded pathogenicity	Probably no pathogenicity
Exon	24
DNA change	c.9242T>C
BIC DNA change	9470T>C
Protein change	p.V3081A
Posterior P	0.005656703
IARC Class	2 - Likely not pathogenic or of little clinical significance
Key Observational Reference	Parsons et al 2019
Prior P reference	-
Missense analysis Prior P	0.29
Splicing prior P	-
Other Prior P	0.02
Combined prior P	0.29
Segregation LR	1.8196
Pathology LR	0.89
Sum Family LR	0.77404129
Co-occurrence LR	1.129287087
case-control LR	0.009839044
Product of LRs	0.013927954
Comments	-

1 entry in BRCA2

Path.

Allele

Exon

DNA change

BIC DNA change

Protein change

Posterior P

IARC Class

Key Observational Reference

Prior P reference

Missense analysis Prior P

Splicing prior P

Other Prior P

Combined prior P

Segregation LR

Pathology LR

Sum Family LR

Co-occurrence LR

case-control LR

Product of LRs

Comments

Unknown

9470T>C

p.V3081A

0.005656703

2 - Likely not pathogenic or of little clinical significance

Parsons et al 2019

0.29

0.02

0.29

1.8196

0.89

0.77404129

1.129287087

0.009839044

0.013927954

Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation