Variants - Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation

Variant data
Allele	Unknown
Reported pathogenicity	-
Concluded pathogenicity	Unknown
Exon	4
DNA change	c.426-12_426-8del
BIC DNA change	IVS4-12del5
Protein change	-
Posterior P	0.065461868
IARC Class	3 - Uncertain
Key Observational Reference	Parsons et al 2019
Prior P reference	-
Missense analysis Prior P	-
Splicing prior P	-
Other Prior P	0.02
Combined prior P	0.34
Segregation LR	0.2856
Pathology LR	0.4761
Sum Family LR	-
Co-occurrence LR	-
case-control LR	-
Product of LRs	0.13597416
Comments	-

1 entry in BRCA2

Path.

Allele

Exon

DNA change

BIC DNA change

Protein change

Posterior P

IARC Class

Key Observational Reference

Prior P reference

Missense analysis Prior P

Splicing prior P

Other Prior P

Combined prior P

Segregation LR

Pathology LR

Sum Family LR

Co-occurrence LR

case-control LR

Product of LRs

Comments

Unknown

IVS4-12del5

0.065461868

3 - Uncertain

Parsons et al 2019

0.02

0.34

0.2856

0.4761

0.13597416

Database of BRCA1 and BRCA2 sequence variants that have been clinically reclassified using a quantitative integrated evaluation